I have moved to .204 Ruger and haven't looked back. For shooting varmints at 400 yards and in....it really performs. Take into account that it uses much less powder that the 22-250. I own 2 Cooper Arms rifles chambered in .204 Ruger....which I reload for. I whack hundreds of prairie dogs every year with them. The accuracy and performance (on paper and in the field) have sold me on the twenty cals. I attended a last year's Cooper Arms One Shot and won my oil painting and several money shoots with my Cooper Montana Varminter rifle. Out of the 40 shooters everyone but 5 shooters were shooting .204 Ruger.
An excellent read below:
http://www.6mmbr.com/20Caliber.html
Treatise for Twenties by Kory Hamzeh, 6mmBR.com 20 Caliber Editor
"Why are folks turning to the "Terrific Twenties"? Among the most important reasons are: low recoil, high velocity, low noise, reduced cost, longer barrel life, and better ballistics for a given bullet weight. In short, compared to a .223 Rem, a Twenty shoots flatter, costs less to shoot, and is easier on the shooter's shoulder and his barrel.
The first time you shoot a 20-Caliber rifle, you'll note that there is minimal recoil, meaning the muzzle stays on target. No loud, dust-kicking muzzle brakes required here. You can shoot and actually "see the show". The rifle doesn't move enough during recoil for you to loose your target in the scope. This enables you to quickly asses the results and make a follow-up shot, if need be. A related advantage is low blast and noise. Even with relatively short barrels, 20-caliber rounds burn less powder than larger varmint cartridges such as the 22-250, and the Twenties make less noise. This definitely works to the hunter's advantage in a large field of ground squirrels or prairie dogs.
I'm often asked how a 20-Caliber gun compares with the ever-popular .223 Rem. Well, I tell people the Twenty is flatter-shooting, easier on barrels, and it is a better choice for small varmints, whether you want to "mist 'em" or save the pelt.
The Velocity Edge--A .204 Ruger drives a 40-grainer 600 fps faster than a .223 Rem can push the typical 22-Caliber 50gr bullet. This higher velocity produces a flatter trajectory. Additionally, grain for grain, 20-Caliber bullets have higher ballistic coefficients than .224 bullets. Combine this with the extra velocity of the 20-Caliber, and you get superior performance in the wind. Run the numbers and you'll see--a 40-grainer shot from a .204 Ruger has less drop AND less wind drift than a 40gr or 50gr bullet fired from a .223 Rem. You'll find the data in the chart below.
Component Economy and Barrel Life--All the Twenties burn way less powder than a 22-250, and the smaller Twenties use less powder than a .223 Rem. This attribute actually has two advantages. First, it makes shooting 20-Caliber cartridges more economical, but mostly it means less barrel heat. A typical varmint hunter may shoot several hundred rounds in one day, so barrel heat is an important issue.
Terminal Ballistics--For hunters seeking maximum explosive effect on a small varmint, Twenties deliver the goods. Because it passes through the rifling much more quickly, a 20-Caliber bullet will be turning much higher RPMs than a 22-caliber bullet launched from a barrel of similar twist rate. Experienced varminters will tell you that high spin rates create the most explosive impacts. On the other hand, if you shoot a non-fragmenting bullet, the Twenty can minimize hide/fur damage. If you plan to keep the fur, you want the smallest possible hole or damage to it."