Hi Rancid...
Your problem in that type shooting is the wind much more so than bullet drop. The amount a bullet is affected by wind is directly due to
how fast it sheds its' speed.
Example...
The Hornady .22/250 40gr. Vmax starts out at a scorching 4100 fps.
The Hornady .243 75gr. Vmax launches at 3400 fps.
But the .22/250 sheds more fps faster, much faster, than the .243.
With a 200yd. "zero", the 40gr. Vmax from a .22/250 will drop 14 inches at 400 yds. A 75gr. Vmax from a .243 will drop 13 inches. Not too much difference there.
HOWEVER...
In a 10mph breeze that .22/250 bullet will be deflected 20 inches at 400yds. The .243 load will be defelected only 13.5 inches - that's
6.5 more inches of "guesstimation" you have to get right with the .22/250. Said another way - the deflection of the .243 load is about
2/3 the deflection of the .22/250.
But let's bump the wind just another 5mph - and 15mph is not at all uncommon in PrairieDogLand.
The .22/250 now has a deflection of
30 inches at 400 yds while the .243 load is deflected only 20 inches - again, about 2/3.
Which would be easier for you to use ?
As for cost...
Some pdog shooters have a high percentage of hits and some have a low percentage of hits. The ones with a high percentage of hits are almost always the ones who take their time and who have a lower
total of shots fired. The ones with a low percentage of hits are usually the ones who fire the most shots (into the dirt and rocks and grass).
When you get a chance - compare the cost of sixty .243 cartridges to the cost of of three hundred .22/250 cartridges and decide which is less expensive.