I recently picked up a Ruger SP101 DA revolver in .22. I'm very pleased with it. Some complain that it's (1) a bit heavy for a .22, (2) it has a six rather than a nine shot cylinder, (3) the rear sight is windage adjustable only and (4) the DA trigger pull is a bit heavy. I've found all these complaints to be vastly over exagurated. For what I was looking for, it fits the bill perfectly. It's very accurate, and like most Rugers it's somewhat over built (which means I doubt I'll wear it out in my life time). You will also find that the Ruger will run $100+ less than a comparable S&W.
In terms of accuracy, I've found Autos and Revolvers to be similar (those with like sights, barrel lengths and frame sizes) when shooting single action. Many find accuracy is diminished a bit when shooting a revolver in double action (due to the longer & heavier trigger pull required). But even this is over come with practice.
Down the list from S&W and Ruger is Taurus. Where Ruger is less expensive than a S&W, the Taurus is less expensive than the Ruger. However, Taurus does offer DA revolvers in .22 Long Rifle and .22 Magnum. And there are more options in sights, finishes and barrel lengths. I probably would have gotten one if I hadn't run across the deal I did on the SP. Most people (like 80%) from what I've read on these boards like them. They seemed a bit fragile compared to the "tank like" Ruger to me though. But, they are probably the best value in a moderatly priced, good quality revolver.