I carry a NAA Mini in 22 MAG, daily, usually in addition to a sub compact .45 ACP. I call it my "everywhere" gun, sometimes I almost forget it"s there.
Here in SW Floriduh, we don't wear a lot of clothes, so hiding even a compact .45 can be a challenge some days. The 22 MAG easily lurks in shorts and a T shirt. The berreta, not so much.
I have put down everything from pests to injured livestock with the .22 MAG. I consider it a viable self defense weapon, close in, primarily, after after I have already screwed up and let an assailant/attacker get way too close... (I call it my "let go of my shirt, you SOB" gun)
IMHO, the .25 can kill, the .22 MAG, in a similar sized package, is better at it. Distance performance goes up as the bore get's over .30 and closer to 1/2 inch, but so does bulk.
My favorite weapon is the one I have at hand when I need it. I'm anxious if I have less than 2 full reloads in hand, for the weapon (s) I'm carrying, but that's just the way I move thru life...
If you allow your significant other to restrict or reduce your ability to protect and defend your family, (for whatever reason or purpose) perhaps you have bigger problems than a shortage of ammunition. (Just one man's opinion)
Paul