Not really. My dad started reloading before I did and he used to brew up loads for my 03 Springfield. He'd make rounds with a 180 gr. over 45 grains of IMR 4064, then 46 grains, 47 grains, and 48 grains. I'd shoot a few and then move on to the heavier ones, but I'd shoot them back to back.
I'll tell you this. The difference ONE GRAIN of powder makes in recoil can be noticable. While I wasn't to the point where I could tell him the exact powder charge, I could easily tell him whether the round he handed me was stronger or weaker than the one before.
And before anyone pipes up with something crazy, I regularly shoot my 6 pound .444 Timber Carbine (which, incidentally, some lunatic tried to sell for $2900 on auctionarms recently) which has a fair bit of recoil to it