I've shot thousands of rounds of 30-30, 30-06, 308, 30-40, and 30MI carbine using hard cast bullets (which I cast myself). I'm keeping my eyes open for a plain based mould as the price of gas checks has gone up about 400% from when I bought my last ones.
Don't try to push them as fast as jacketed bullets, use Hornady gas checks (or even Lymans, I like the Hornadys as they crimp on tighter) and use a good lubricant (I use the old Alox/Beeswax stuff). Should be little or no leading and it can be taken out with a couple of jacketed bullets fired after a day at the range (unless it is severe, the leading).
I use mainly IMR4198 in the bigger cases, and Unique in the smaller ones.
Have a pre-64 Model 70 in 30-06 that can give me inch and a half groups with carefully prepared loads (Lyman 311291 sized to .310, linotype bullets cast, heat treated and lubed with Alox, and the proper charge of 4198 with a tuft of Kapok on top of the powder).