Sight in at 3" high at 100yds
the round (158 gr jsp s&b) doesn't cross the line of sight until it crosses 171 yards.....i.e it's a dead on hold. It's only a little low at 200yds .Most people are surprised by how flat the .357 from a rifle can shoot, relatively speaking. Also Your not really getting down to handgun velocity until about 150 yards ( and most people will tell you the .357 from a HANDGUN is suitable for whitetail to at least fifty yards) , IIRC, from my own chrony work. Personally I wouldn't hestitate to take deer at that range(170yds)........as always though if you can't land your rounds in the right spot........ I personally get 2.25" groups (from a rest with aperature sights, s&b ammo) with my 1894c at 100yds, a scope might improve that a bit.
With the new pointed flex tip ammo it's shooting much flatter. With the Buffalo bore heavy stuff I wouldn't hesitate to use it on elk at shorter ranges (under 100 yds)