I have a 375 H&H, it's a Mark X Whitworth express rifle, I bought when I was 21 or 22 (I'm 38 now) for about $400 and it wil always live where I live. It is a classic, Mauser action, 3 leaf express sights, barrel band sling swivel, oil finished stock and a red recoil pad. It weighs just shy of 10lbs and is relatively easy on the shoulder.
The only load I have ever shot out of it (besides a single box of Winchester 300gr factory ammo to get the first lot of brass) is a 300gr bullet with 80grs of IMR-4350 (that load is above current reloading manual maximums, I do not recommend it, just stating what I have used safely) in Winchester brass and a Federal 215 primer. With the iron sights, it'll do 1 1/2" at 100 yards.
I've never had the pleasure of hunting dangerous game with it (as a young man I bought it with that intention but it hasn't happened yet), but I have shot a few whitetails with it. It actually destroys very little meat. Far less meat than some of the 30/06s, 35 Whelens and other rounds that I've used on deer.
The 375 H&H is a great round and my rifle is a thing of beauty. It is a great joy to own and hold and handle and look at and shoot. What more could you ask for? And if or when I do get the opportunity to hunt something that bites back, I'm ready.
W101