Just tested a batch of 180g Bear Creek Moly coated RNFP over Bullseye in a 4.25" M&P40.
"Full house" load was 5.0g Bullseye 1.135" COL (.280" seat depth). Predicted pressures were 26,250 psi (25% below SAAMI max), predicted velocity was 1002 fps.
Actual velocity averaged 992 fps ES 9 fps, SD 4.3 fps. Moderate recoil, and lighter recoil than 6.0g Power Pistol which generated only 962 fps. Also shot some with 3.8g Bullseye and those averaged 850 fps with an even more gentle "springy" flip.
While Bullseye is a denser powder than Unique or Red Dot which will spill over with a double charge, a double charge (10 grains) of Bullseye will definitely be noticeable unless you use an automatic bullet feeder so I don't find it risky to use.