My side of the bed has had a 296 loaded with those Blazers/GA 200gr GDHP's for years, while my wife's side had a 2" 10 with 158gr LSWCHP +P's. Since she hates shooting that 10 so loaded, I added a revolver she likes to shoot - my 5.5" .45 Colt Redhawk - with 255gr LSWC's and 250gr GDHP's - both at 850-900 fps. I think she likes the intimidation factor, although I do agree that it is an easier shooter than the 2" 10.
I really wonder just how good 240gr LSWC's from a .44 Special would be as 'stoppers'. My .44 Russian 'poof' loads, making 692 fps from my 3" 696 - and 'major' power factor, are an easy shooter for anyone. They can get to 780+ fps easily, but even that slower variant would probably do. I did try five similar 240gr LSWC bullets in .44 Special cases from my 296 - no topstrap damage or deposits were noted, although some lead was present around the cylinder bore exits on the Ti cylinder, and were difficult to clean. Pulling the remaining rounds after each shot revealed that at the fifth shot, it's crimp was letting loose. Glad it wasn't a six-shooter. Back to it's Blazer/GA 200gr GD menu.
So - if you have a .45 Colt, don't discount it. Still, a good .44 Special, if you can find one, or a 4" 629, MG or not, is a great choice, too.
Stainz