The organic gel formula used for modern handgun ballistic testing (10%) was developed to simulate swine (porcine) muscle tissue, not bone or hide. If you want to vary the test medium methods, don't be surprised if the results vary from those produced when other mediums and protocols are used.
Dr Martin Fackler developed and refined this testing medium when he was the head (and founder) of the Wound Ballistics Laboratory for the Letterman Army Institute of Research. Even carefully mixed, maintained at the proper temperature and 'calibrated' (penetration of BB fired at specific velocity), it wasn't promoted or guaranteed to be an exact model of the obviously non-homogeneous human anatomy, but was designed to roughly approximate swine muscle tissue (thought to be similar to human muscle tissue).
If test protocols and materials are substantively changed, expect potentially different 'results'.
Even when the FBI was working with surgeons and other medical professionals during the development of their own gel testing protocols, the SSA writing their original in-house paper on wound ballistics recognized the importance of looking at both lab results and reports from actual shooting incidents, and didn't consider the results of lab gel testing to be the exclusive or definitive answer to wound ballistics questions. Testing methods for examine potential new duty ammunition, yes, but not something to answer all questions involving wound ballistics.
Gel testing can help you observe what a bullet may do when observed within the specific protocols of the lab testing (or, what the medium may do to the JHP bullet under similar conditions).
Now, when the 4LD denim/gel testing was later conceived and designed (not part of the FBI protocol), it was subsequently observed there was a correlation between recovered lab test JHP's and some JHP's fired in actual OIS incidents. No guarantees. No promises.
Also, the way a JHP bullet is acted upon by the medium into which it's fired doesn't exactly let someone 'predict' how a live organism (human or animal) may react when experiencing the GSW.
If you want to use your own informal testing methods and materials, you're basically on your own. Just like in earlier decades.