Unless you're defending against marauding Moose or Elk, or need to seriously attempt to disable a vehicle - no. In fact, home/small area perimiter defense is one of the few roles I actually like a pistol caliber carbine for. The greatest advantage of the 6.5/6.8/.450/.458/.50B calibers is their ability to deliver a real punch at extended range where the 5.56 doesn't.