Make sure your fail safe rod is adjusted correctly and you're getting full throw of the powder slide both ways.
#1 reason for variation is if you don't have the two screws on the collar that holds the powder measure tight. I used to leave mine a little loose to let the measure "float". Thought it was no big deal. Problem is, it can move up and down a differently with each pull.
Once I kept it tight and adjusted everything correctly, it's typically dead on. Worst case +/- .1. I've got 4 Dillon measures.
Also, I load rifle one round at a time. Too much stuff wiggling and flopping with the four long cases standing up. For example, if you don't get the case in station 1 lubed correctly, it will take a harder pull and change your rhythm.