I would tend to concur with Tony's comments.
If you were to define ranges of fire, my thoughts would be
Zone I - 0-300 meters
Zone II - 300-500 meters
Zone III - 500-800 meters
Zone IV - 800-1500 meters
Zone V - 1500 + meters
If we look at Zone I, the 5.56 NATO 77 Grain, I think more then fills the need. Will the 6.8 SPC or 6.5 Grendel offer improvement in this zone? Yes, but mere fact of higher projectile weight.
Looking at Zone II, the 5.56 NATO, 77 Grain has entered the zone of questionable effectivness. Again, the 6.8 SPC does better by virtue of heavier bullet weight, but given similar ballistic coefficients of both bullets, it must be launched within a defined velocity window (equal or lower to a point) to maintain its advantage. The 6.5 Grendel, by virtue of the higher ballistic coefficient bullets of similar weight to the 6.8 SPC, has the advantage in this Zone.
Stepping to Zone III, the 5.56 NATO is beyond it's capability other then maybe harrassing fire. Even at the advertised level of 2800 fps for the 6.8 SPC, my own long range shooting experience tells me that a .340 BC is not the best choice for this range of fire. The 6.5 Grendel was designed to run in this range and the ballistics of bullets lets it perform. On a scoped M16, the 6.5 Grendel would be a solution for designated marksmen. On a M16A2-A4 when using iron sights or non-magnified sight, aimed area fire would be reasonable and achievable with the 6.5 Grendel and the projectiles would be far more effective then 5.56 or 6.8 bullets due to higher retained velocity and energy.
In Zone IV, my own personal preference would be the .338 Lapua Magnum for precision shooting. While the 6.5 Grendel will run to 1,000 yards supersonic and can take aimed shots, but for this total range zone, the 6.5 Grendel would be best for area fire and it can do this in a M249 like platform.
In Zone V, this is the land of the 50 BMG and even the 338 Lapua Magnum.
As someone else says, just my 2 cents.
Edited to add,,, not one penny of US Government money has been spent on the development of the 6.5 Grendel. In addition, the 6.5 Grendel rifles and ammunition presented to the government are production models that are the same being shipped to civilians. The government may choose to configure rifles and ammo to meet specific needs, but they will have a production model to work from, not a prototype.