Gtscotty, I bought 16lb of Reloder 17 a few years back with the plan to build a .260 Remington for F-Class. I bought a Badger M2008 action, a Krieger barrel and an AICS stock but then moved to an area where there wasn't a good, local F-Class scene. I ended up selling the barrel, action and stock for no loss but kept the powder. If not for that, I would have been looking for H4350. As it stands, I have enough powder for the life of this barrel i.e. 2,500 rounds so will stick with this load unless it proves to be very temperature sensitive. I need to test for that. When I worked at Remington we would test at -20°F, ambient (~70°F) and 150°F. That's a much harder test than most will subject their ammunition too but that was the spec.
As for annealing, I have a Fluxion "Annie" annealer. So far it's proven to be very useful. I'm still learning some of the subtleties of the machine but overall it's extremely convenient and seems to do a good job.