When I was a lot younger and a great deal more stupid, I shot a pretty fair number of deer and antelope with each of 4 different cartridges with target bullets (222, 6mmRem, 30-06, & 300WM). I was shooting Sierra HPBT in all cases. They did, and still do yield superior accuracy over hunting bullets.
The construction of the Sierra HPBT is very similar to the Nosler Custom Competition and the Hornady A-MAX (except this has carbonate tip), they all have very thin skins that are the same thickness almost to the base. The terminal effect upon impacting skin, meat, and bone, was that the bullet will expand rapidly, the term "blows up" is probably more accurate. As to the term to describe the terminal results on meat, "like throwing hand grenades', extreem disintergration of the bullet with fragments imbedded over a wide area of the wound channel. It is not like the nice wound channel in ballistic gelatin. It is fugly!
They almost always gave a very rapid kill. But these shots were always well placed. I hate to think of the agonizingly slow death that marginal flesh wounds (like just a crease across the back) will procuce with this bullet.
My advice (for what it's worth) from a performance and ethical view point is shoot hunting bullets when hunting!