If both are available, why choose one? I think a double-stack autoloader makes an excellent back-up for a good fightin' sixgun. Yes, that does mean I would prefer the sixgun, but in a true nightmare home invasion scenario, there may be need of more than six rounds, and a second gun postpones the need to open that cylinder for a reload.
After it became mandated that I carry an autopistol in my duty rig, on the PD job, it was, and still is, OK for me to carry a sixgun for back-up purposes. From 2000 to 2007, I kept a .357 sixgun cased, in the front seat area of my patrol car. Several felons have
looked up the barrel of a big GP100 while the duty auto remained holstered.
I am not not anti-auto, I just prefer sixguns for certain things.