I carry a couple of striker fired guns, fully loaded, daily, and shoot them all the time, and have never had an issue in either department.
I presumed you were referring to a Colt 1908 Vest Pocket, Baby Browning, or something similar. These have a long nose on the firing pin that doubles as an ejector. Quickly snap back the slide to eject a loaded cartridge and you may get a nasty surprise as the half-chambered round goes off.
While unlikely, if both the manual safety and grip safety (if they're is one) fail because the striker/firing pin cracks there is nothing to stop the striker from going all of the way down. Once you cycle the slide there is no way to decock the piece except pull the trigger.
Hopefully you remove any chambered round first...