It's pretty well detailed in the "Tuning a Pietta for Competition" articles. Basically, Pietta cuts the locking notches in the cylinder to a width of about 0.143", but then makes the cylinder bolt out of 0.155 stock. They then leave the leg on the bolt that rides on the hammer cam too long, with the result that the bolt is released just when the hammer reaches full cock. What happens then is that the too-wide bolt crashes up into the cylinder locking notches, and in short order hammers the locking notches over.
Not only does this mean that the cylinder locking notches are eventually damaged, but the cylinder is not really locked. It is only held in place by one side of the bolt, and the other side is held by the hand, whose entire job should properly be to rotate the cylinder. But what happens next is that, when you pull the trigger and the hammer falls, the hammer pulls the hand back down. But the hand spring is still pushing the hand against the ratchet on the back of the cylinder, and the potential exists that the cylinder may rotate backwards just a little. So when the chamber fires, the ball then crashes into one side of the forcing cone. Not good, as it likely stresses the arbor unnecessarily.
It's easy to test for this. Just cock the unloaded revolver, and while slowly lowering the hammer, use your other hand to try to rotate the cylinder backwards. If you can do so, then your bolt has to be refitted.
If the cylinder notches are too beat up, then you may need a new cylinder, which Cabela's usually sells for $49.
But don't try to refit your bolt or clean up the notches with a Dremel. Go to Home Depot and buy a set of Nicholson precision files.
What is supposed to happen is that, first, the bolt should come off of the cam well before the hammer reaches full cock and before the cylinder aligns with the barrel. The bolt then snaps up into the lead-in grooves and is pressed up by the pressure of the bolt spring - that's why those grooves are there. Then, when the hammer reaches full cock and the cylinder aligns with the bore, the bolt is pushed up into the locking notches gently and without causing damage.
By the way, I don't do the hand spring replacement that the tuning article details. So far I've never had a hand spring break.