Howdy
Yes, Uberti proofs all their firearms in government proof houses to standards that exceed our SAAMI standards. So in theory, anything they make should be fine with standard ammunition sold off the shelf here.
HOWEVER...................
This is a Merwin Hulburt Pocket Army that left the factory some time in the 1880s. As you can see it is an open top design. It is chambered for the 44-40 cartridge. If you look very closely you can see the barrel/cylinder gap is a bit on the wide side.
I don't have it in hand right now, but I seem to remember the gap is on the order of about .012 or so.
I am quite certain this revolver did not leave the factory with a gap that wide.
What has happened over the years is something has bent. No, the arbor is not being yanked out as can happen with brass framed Cap & Ball revolvers.
With this design, the arbor does not lock the barrel in place. The barrel slips over the arbor, but the rotary joint at the bottom of the frame is what keeps the barrel snugged to the frame. Over the years, something has actually bent to open the barrel/cylinder gap to where it is now. I suspect the lower portion of the barrel has actually bent a little bit. And that has resulted in the overly wide barrel/cylinder gap.
Clearly, this old revolver is not made from modern steel, as a modern Uberti is. That probably contributed somewhat to the wide gap. In fact, the next version of this revolver did have a top strap, with a similar rotary joint at the rear of the top strap. This was added because it was recognized that a top strap would make for a stronger gun.
Just a caution, about Open Top revolvers.
Yes, I do shoot it, but only with ammunition loaded with Black Powder.
By the way, a friend has a couple of Uberti Open tops, chambered for 38 Special that he shoots all the time in CAS. But he only shoots them with Black Powder.