For any extensive use, or use with high pressure ammunition, there is another problem with the open top revolvers. When a percussion gun is fired, back pressure is exerted on the whole cylinder, which recoils into the middle of the frame boss, which is not only strong but is lower on the frame.
When a cartridge revolver is fired, the pressure is exerted on the cartridge case, forcing it back against the top of the frame and exerting greater leverage on the frame as a whole. In other words, the frame tends to bend or break at the lower rear corner.
That is the main reason Colt went to a topstrap revolver for their 1873, since experience with the open top revolvers and metallic cartridges had shown that the top strap was necessary. Of course, the top strap allowed a solid frame and dispensed with the other area of weakness, the center arbor and wedge system, so they dealt with both problems at the same time.
Little did they dream that anyone would want to go back to the old system because it was "cool."
Jim