My favorite shot, if it is presented is a heart lung shot. Generally they jump once or twice and fall or take a few steps and they are down usually 25-40 yards. But there are several exceptions. Once I shot a young buck about 160 lbs with a 30-06. He spun around and took off headed off the field and into some woods. The bullet went all the way through and left a huge wide blood trail. He went about 100 yards and was piled up dead. Turns out the shot separated the heart from from the vessels and also mushed up both lungs. One of the most recent deer I shot was a doe about 20 yards away walking. Hit her in the same place with a sabot slug. Dropped like a rock right there dead. I am a believer in the bigger and faster is better, but you just never know how a particular deer will react. My son shot a doe end to end through the chest with a 7MM mag and had to call me to track it. It went about 200 yards but it was in thick cover with no snow. I have had the worst results with slugs but I have had DRT's too. I like that it is not cut and dried. Bullets and critters do strange things sometimes.