Only Ruger handgun I have experience with is one of their P-series 9mm, and it feels kind of clumsy and awkward and muzzle heavy to me. But, I'm very inexperienced with handgun shooting, and Rugers have a reputation for being very beefy. I'm sure it's a fine gun, just not for me, with small hands and all.
I do own a Ruger 10/22 and love it, but this thread is about handguns, not rifles, so I'll leave it at that.