I have always shied away from magnum rifle calibers after something I once witnessed at a range during my time in Michigan. A gentleman was sitting at a bench attempting to sight in a very nice rifle chambered in .340 Weatherby. Nothing too odd there -- at least until I looked a bit closer.
He would fire a shot, wait a few seconds, pull out a handkerchief, and wipe the blood from his nose. Once his nose stopped bleeding, he would repeat the entire process. I thought he just had a nosebleed from a sinus infection (common during the long Michigan winters) and thought nothing of it until it was time to change the targets during a cease fire. We talked about what each of us was shooting; I had my Remington 700VS in.308, and he had his rifle. I asked him if the recoil of his rifle fired from the bench was tough on his shoulder. He laughed and told me the recoil was tough on his whole body. He said his nose bled every time he fired that Weatherby, from the bench or not.
That made an impression on me. My hunting rifles are chambered in .308 Winchester, .243 Winchester, and .35 Remington. I have never needed more rifle, but I have limited myself to deer. I have a .375 H&H, but I have never taken game with it. Perhaps some day I will.
This year I will be using my Browning 1885 in .243 Winchester. Same as last year.