I voted for, and carry Hydroshocks, mostly because that's what I can find most of the time in most any gun shop and I've tested them enough to know they cycle fine in my .45.
Placement, placement, placement.
Put 'em where they'll do the most good and I think it won't matter all that much what you're shooting, within reason.
The Powerballs kind of caught my attention in ads, but I have yet to see a box on the shelf. Of course I reload a lot so its been a few months since I looked for any "store bought" ACP.