Are you looking to maximize terminal effectiveness? DoubleTap sells a 250 grain hollowpoint that gets 1450 out of a 7.5" barrel and 1775 out of a 16" barrel. If you are worried about penetration, you can certainly also get their wad cutters that are about the same weight and speed. Out of a rifle, recoil is not too much of a factor in my Trapper.
I have some of those Georgia arms loads - the 200 grain and 260 grain. Out of a pistol, the 260s are pretty hot. I would much prefer to use the 200 grain / 1100 fps rounds for self defense against people: they are easy to control, and the performance is plenty. I would anticipate more like 250 or 300 fps gain from a rifle, based on extrapolation from the DoubleTap and Buffalo Bore loads.
I like the Georgia Arms 200 grain loads mostly because they are a high quality load in .45 Colt that is not either a totally maxed bear blaster or a wimpy cowboy load. Out of my 5.5" Blackhawk they are very accurate - I kept them in the 9 ring at 50 yards today, off a rest, using open sights. I personally think they seem like a very good self-defense load.
But, if you are trying to stop a runaway cement mixer, the DoubleTap loads are the way to go.