Alliant 2400.
Next question.
But seriously, in my 4" GP100, I load a 158 hardcast LSWC with 14.0 grains for 1244 fps with an ES of only 38fps, or a 180 hardcast with 12.0 grains for 1149 fps with an ES of only 30fps. Both loads were developed using CCI 500 and are near-max or max loads, depending on source. I stopped moving up because they were accurate and developed the velocity and consistency I wanted, with no pressure signs.