Have you handled all three? If not, I'd recommend trying to locate them and do so. One of them may feel like you're shooting a gun designed for gorilla hands, and one may have the controls out of reach for you, or too close and cramped depending on your hands. Gun fit, especially with double-stack, big bore autoloaders, is a big deal to me. They tend to have compromised somewhere in order to get a dozen or so .45 ACP cartridges into a "grip".
Also, decide on which trigger/safety setup you like. I may be wrong, but I think eack pistol here is different. None of them are "wrong", and none of them are the "best". They're just different.
Ruger = Slide-mounted Manual Safety
FNP = Double-Action/Single-Action w/ dual-purpose Manual Safety/Decocking Lever
M&P = Double-Action Only. No Manual Safety.
Think about what that means in regard to carry, HD, and the range. If you're not sure, say so, and I'm sure somebody could give an opinion on the safeties & triggers.