No.
I mean, what's the point of that much mass in a bullet being launched in a rainbow trajectory from a rifle that most likely doesn't have the sights to compensate?
A 500 grain .45 cal bullet, I can understand. Maybe the 460 gr 50 cals are for folks who put flip-up receiver sights on their 50 cal rifles?
Inside of 150 yards or so, I don't see any real advantage to such a massive bullet. Beyond that range, the extra weight *could* be an advantage, except that 50 caliber is typically not used at those ranges.