For what it's worth, which probably ain't much, but my truck gun is a Ruger American in 308 and I'll take a shot with confidence at a deer, coyote, groundhog, fox or whatever farm varmint that needs to be removed out to around 300 yards using a fortune cookie and a solid rest.
I got mine on sale years ago at Rural King and put a Leupold Redfield scope out of the local Cabelas bargain cave and have less than 500 in the whole rig and it shoots better than some pretty pricey rifles I've handled. In fact I would go so far as to say it's the most accurate rifle based on what it cost than I've ever handled. I was just putting together a cheap truck gun and very pleasantly surprised at it's accuracy. I do use handloaded ammo but never really worked up a load specific for it, it just happened to like a load that I always loaded for another rifle so I stuck with that.
I would have rather had a 7-08 but they didn't have any more during the sale at the time so I got the 308. If you don't reload then the 308 would be better anyway.