To be honest, I would pick out the closest weights and profiles to what you normally shoot. Start off with the Lee 2 cavity molds to get your feet under you and figure out the finer details for your sizes and loads. If you like what your seeing and doing, then progress into the other molds like NOE, Accurate, and so forth.
I have close to 2 dozen Lee molds and about that many MP brass mold with a few from Saeco, Lyman, NOE and Accurate thrown in for good measure. In the calibers I shoot the most like my 45 ACP, Colt, 41, 44, 38 and 357, I have at least one Lee 6 cavity for each. When I pour up a batch for any of them I usually will do around 12-18# worth, and use as needed.
The Lee 2 cavity molds are better built than they were a few years back. They redesigned them and they have a much better fit and function. They come with handles attached where the 6 cavity ones need to be purchased separately. Even so one or two set of handles can easily be switched between several molds.
For production you can hardly beat a 4-6 cavity mold, but they DO cost a bit more, especially when you start looking at the more or less customs. With the Lee you will still get quality bullets that are great for plinking and even hunting, but your limited to what they produce.
One last thing to keep in mind, if you find a profile you like, don't worry about if it is listed as a tumble lube or not, any of them can be tumble lubed with the Alox or a blend of it. Most I think use the 45/45/10 blend as it dries to a non sticky finish. It works well, even if it does smoke a little, but I have had some of the standard type lube smoke just as much or more, depending on the powder and load used.
Hope this helps, and for more info look up the LASC site or Castboolits. Either of them are a wealth of info.