JayCee72, picking out your gun involves a lot of decisions and compromises concerning the things that are important to
you. That said, my recommendation matches that of a few guys who have posted above me.
If I were to have only one gun, it would be a revolver in .357 with a 3" or 4"-ish barrel. Loaded with .38 special it makes an affordable plinker and target shooter. The .38 special is a fine defensive round in its own right, and loaded with the .357 that gun will certainly get the job done.
If I were to have only two guns, one of them would be a .22. They are just plain fun to shoot and a very affordable way to keep practiced. Of course, you still have to keep practiced with your defensive weapon.
If I knew now that I would later have two guns, I would get the .22 first. These little shooters come in lots of flavors. If you know now what kind of gun (revolver vs auto-loader) you intend to get for your defensive weapon, get a .22 that matches. That lets you hone your skills while at the same time getting used to the gun's operation. It also gets you to the range where you can see other guns in use and, very likely, get offered a chance to handle and fire them. Great way to try the fit and feel of something before you buy one yourself.
If I were looking at a third gun, it would be a slim auto-loader in 9mm or a J-frame snubby in .38 or .357 -- something more easily concealed in a wider range of attire. Of course, if that factor is of greater importance to you that might be the first gun. You get the idea. Once you've made those preliminary decisions about type of action (auto vs revolver), barrel length, size, caliber, etc, then you get down to the specifics of Glock-this, Sig-that, or S&W-whatever.
Some of the best gun advice I've seen in print can be found on
Chuck Hawk's web site. Worth your time to give it a read.
Here Chuck talks about the factors involved in selecting a handgun.
Here he gives his personal recommendations. (all opinion and trumped by your own preferences.)
Here he talks about choosing a gun for home defense, and
here he talks about concealed weapons.
Another great source is
Cornered Cat. Between these writers, I'm sure you will find advice in there that will be useful in making up your mind about what is right for you.