Depends if you are shooting specials out of magnum cylinders......
Pable makes a good point about extra cleaning attention for the cylinders, if you've been shooting .38's in a .357, as you can get build-up at the end of the cycliders that could restrict the longer .357's.
That being said, from what I've read, it still takes a while for this to be a possible issue, so you probably don't need to attach a bronze brush to your Black & decker drill and spin-out the cyclinders every time you shoot 50 rounds .
(Though, from what I've read, this method does seem to be a popular way to do it.)
Anyways, it took me YEARS to ween myslef off the obsessive degree of cleaning that was hammered into us in the Marine Corps. My freinds used to find it highly amusing watching me make such a production ( "really,dude? Q-TIPS" ??) out of cleaning a gun after shooting a few rounds, but I've finally relaxed a bit.
I still like to clean after every shoot, but i've been known to let an AK or SKS go a bit before cleaning, even shooting them a couple times before getting around to cleaning them.
These days, with most everything else, I will often just run an oiled patch through the bore a few times, till it comes out semi-clean, and wipe everything down. I may or may not run a bronze brush through a couple times.
If I'm not likely to shoot the thing for a long time, I'm more likely to give it the full treatment (soak with solvent, run brushes w/patches till clean).
It's important to keep some perspective, and not get carried away, remembering that these are still just metal machines. They're made to run with a degree of fouling, from the very first shot. None of us would consider disassembling and cleaning our car angines after every ride.