I had a 4" 38 that I put 15,000 rounds of standard pressure through without problems. I suspect that +P rounds generate a little more pressure, but you probably won't live long enough to wear one out. I know the feds had a +P+ round back in the day, as evidenced by the Federal once-fired 38 brass that I got from a federal firing range a few years ago. I believe it was 110 gr. stuff. Now, that was pretty peppy I imagine, and they weren't shooting Colt D frames. A steady diet of those in a D'Back wouldn't be a good thing, but I have no doubt it could handle the pressure a few boxes a year without accelerated wear. Fine little guns, to me, just the right size. The 2.5" 38 was sweet, also.