Howdy
The diameter of the cylinder of the 1858 Remington will not allow six 45 Colt chambers to be bored straight through without the rims interfering with each other. Ken Howell solved this problem by angling the chambers 1/2 of one degree out at the rear. The idea of angled chambers was innovative enough that Howell was able to patent it. This type of conversion cylinder has a backing plate with multiple firing pins. The backing plate rotates with the cylinder. To reload you remove the cylinder from the gun and pop the backing plate off. Just like Clint Eastwood did. It is very quick and easy.
When I bought this type of conversion cylinders for my pair of Remingtons, they were being produced by Howell under the name R&D and sold exclusively by Taylors. No, the slight angle does not cause any problem when the bullet reaches the forcing cone.
A few years ago Howell sold the angled chambers patent to Taylors. Taylors has somebody else producing the cylinders now. Because of the patent, Taylors, the owner of the patent, is still the only company that can produce a six shot 45 Colt cylinder for the 1858 Remington.
http://www.taylorsfirearms.com/cartridge-conversions/1858-remington-conversion-cylinders.html
Ken Howell started his own company to produce conversion cylinders, but because he does not own the patent for the angled chambers, he cannot produce a six shot, 45 Colt cylinder for the 1858 Remington. His 45 Colt Remington cylinders are five shot.
http://www.howelloldwestconversions.com/shop/productinfo.cfm?catID=261&productid=822&cfid=802158&cftoken=7fe1c673ab9fd93-175B8866-C29F-29A9-68A5CDA64E86DF88
Howell does produce a six shot cylinder for the 1858 Remington, but it is chambered for the 44 Colt cartridge, not 45 Colt. Using this cylinder in the 1858 Remington requires using 44 Colt brass and either heeled bullets, or hollow based bullets that will expand and fill up the rifling. This cylinder does not accept 45 Colt cartridges.
http://www.howelloldwestconversions.com/shop/productinfo.cfm?catID=261&productid=816&cfid=802158&cftoken=7fe1c673ab9fd93-175B8866-C29F-29A9-68A5CDA64E86DF88
Kirst cylinders are completely different, they employ a backing plate with only one firing pin that is attached to the frame and does not rotate. Kirst 45 Colt conversion cylinders for the 1858 Remington are also five shot because of the rim diameter issue. Because the Kirst design uses a fixed backing plate, he also offers the option of adding a loading gate. A loading gate will not work with the R&D/Taylors/Howell style cylinders because the multi-firing pin backing plate rotates with the cylinder.
http://www.kirstkonverter.com/1858-remington.html
All of these cylinders are rated for Smokeless 'Cowboy Loads', what ever that is, because there is no SAAMI standard for cowboy loads. Most specify 800 fps or less, but that is meaningless because it does not specify pressure. Some Cowboy Action shooters load their Smokeless loads ridiculously light, commercial cowboy loads are more powerful than these mouse farts.
My 45 Colt Black Powder loads are quite stout, with about 35 grains of FFg under a 250 grain bullet. So stout that I usually shoot 45 Schofield rounds in my Remingtons, with about 28 grains of FFg under a 200 grain bullet. With full power 45 Colt loads I find the grip shape of the Remington to be uncomfortable in recoil. Plus, I am not crazy about how thin the steel is where the loading lever pierces the frame of the 1858 Remington. For this reason, I designed the J/P-45 200 grain Big Lube bullet that I use in my Schofield loads.