Well you have certainly touched off religion with your question
I own both a Colt 1911 and an H&K USP Compact .45
I have put thousands of rounds through both.
The H&K is my home defense gun for a couple of simple reasons.
It can be picked up and fired just like a revolver. Just point and shoot. My wife can shoot it without having to remember anything except point and pull the trigger.
On the 1911 you have to decide if you will keep it cocked and locked. Then you have to fumble with a safety. Or you might want to keep a round in the chamber with the hammer down, then you have to cock it. Or you may want to leave the chamber empty, then you have to rack the slide to load it. All of these things are confusing late at night when you may be under stress too.
By comparison to the H&K, the 1911 is a dinasoar. It is, to be certain, a great dinasoar. But it has not changed much, if at all, since 1911. Oh sure, details like metals and of course you can spend a fortune on one making it a target gun or a "tactical" gun. But for sheer utility, the H&K spits out the potent .45 round accurately and reliably.
I don't think reliability is an issue here. Its ergonomics. Do get an H&K in your hand to see if it fits you.
And, as for cleaning, the H&K is utter simplicity.
After you get your H&K, make your next .45 a 1911. They are a lot of fun and they are relatively easy to detail strip and perform upgrades on (within your skillset of course).
But for what you describe, get an H&K.