Definitely, get out and shoot that shotgun. Start out with light loads and work your way up to something with more oomph, but get started shooting it and getting very familiar with it- before you need it.
At typical home defense ranges measured in mere feet, any reasonably large shot (#4s or bigger) will likely do the job. I personally do not recommend small shot (aka birdshot) for defensive use, as I have heard of instances where it failed to stop. I personally prefer buckshot, and heavier pellets at that- 00 or 000 in 12 gauge loads. Theoretically #1 buck is best because it gives you a higher pellet count of larger sized pellets than other shot sizes, but I have never had any luck getting it to pattern the way I like so I don't use it. I like load/gun/choke combinations that will keep a buckshot pattern on a dinner plate at 25 yards. No, I don't live in a palace- but if a fight begins or moves outside, I want to be able to have some 'reach' with buckshot before I have to transition to slugs. Tight patterns at 25 yards translate to tight patterns closer in as well, and I like tight patterns. Some folks are genuine scattergun aficianados, nothing wrong with that if that is what you want.
I don't care for 'candy cane' loading either. I want to know for sure what's coming up next on the lifter. I keep magazines loaded one short with buckshot, SideSaddles loaded with slugs and chambers empty. That way I can get what I want when I want it.
I have been very happy lately with Hornady's TAP 00 loads, the red-hulled variety. These loads have gotten troublesome barrels on two different guns to shoot acceptable patterns for me, and that's good enough for me to recommend trying them to anyone. BTW, I seriously recommend patterning your gun with whatever you plan on using for HD, even if it's reloads of Tactical Tic-Tacs- that's the only way to KNOW what a given gun will do with a given load at a given range. These Hornady shells are 8 pellet 00 loads at 1600 FPS, not reduced recoil in the strictest sense but very manageable. The Federal 00 and 000 low recoil loads using essentially the same wad design are supposed to be quite good also, though I haven't tried them yet. Fiocchi's low recoil 00 load has been quite satisfactory in several guns I have tried it with. But different barrels will 'like' different loads, best way to find what your gun likes is to pattern it and see.
As for slugs, my hands-down favorite is the Kent/Brenneke KO 2 3/4" one ounce offering. This isn't a low/reduced recoil load either, it's advertised MV is 1620 FPS. I like it best for its sharp-shouldered hard lead alloy slug that cuts full diameter holes, and for its inherent accuracy. I'll put up with the pounding it delivers to get those advantages.
Stay safe,
lpl/nc