best explanation I ever heard, 1911Tuner
IIRC, Colt came out with the Python to compete with the S&W 27. They did a truly beautiful job of it, craftsman class material, fit, and finish; one of the truly fine revolvers of all time. But their thinking on lockwork was a tiny tad off base, and if the Colt design could be said to be flawed, it was the design "philosophy" that was flawed.
We just love appealing phrases like "locks up like a bank vault" etc., but vault doors and revolvers are very different things with very different purposes.
Which is why some folks will label the fine Colts as "fragile", causing others to feel offended. "Fragile" carries far too strong connotations (they ain't made of glass), but the Python lockwork design is simply not as robust as some. All handguns will eventually wear, and all will wear a bit quicker if fed a lot of hot loads near their design limits, but some do wear quicker than others.
Advantage OP (CPE), who owns both collectibles and shooters. If you own 'em, especially in multiples, shoot 'em; if they break fix or replace 'em, that's the way to go, you aren't going to live forever.
Still, for me, a k-frame woobie guy, my k-frames are 'real' magnums, but I acknowledge their limits, so I shoot 357s through them only sparsely. Enjoy 'em too much to wear them out prematurely, and cannot afford replacements unlimited. All that aside, there is no shortage of highly accurate and much tougher 357 revolvers to be had that will handle order of magnitude higher round counts of full magnum loads no problem, just as various posters above have mentioned. Enjoy 'em all.
If you got 'em, feed 'em
(but if you have only one, discretion may be the better part of valor)
PS
re: "if could be said to be flawed.. design philosophy"
depends of course on what philosophy you favor
race cars and race guns break more often than 'turtle' guns and 'turtle' guns (as should be expected), and there are a whole lot of in-betweens
you pays your money and you makes your choices