A properly designed magazine can be left fully loaded for its entire service life and be in the same condition as if it was left unloaded the same amount of time. An improperly designed magazine may overextend the spring when fully loaded, bending the spring, but that would be specific to that design.
What is "properly designed?" Is it a spring that's intended to last the life of the gun, or a spring that has been tweaked so that 18 rounds can be fit into the space originally designed to hold 15 rounds?
The quoted comment above -- as a general statement -- was once valid, but may not be nowadays, with the new emphasis on smaller weapons and higher capacities.
IF the gun designer has chosen to sacrifice spring life to gain capacity -- as is clearly the case with some pocket guns and sub-compacts, some of the recoil and mag springs in those guns will eventually lose some of their resilience (power). And even though the spring will eventually lose its ability to work as it should, it was PROPERLY DESIGNED -- it's design was focused on "more capacity" rather than "long life."
For standard capacity guns, like most full-size 9mm guns holding 10-rounds, or 1911s holding 7 rounds, such mag springs will arguably live longer than the shooter. For some of the sub-compacts and some hi-cap mags (depending on the design), the springs will work for a good while, but may eventually soften a bit, leading to malfunction. What causes this? It depends on whether the springs, when the mag is fully loaded, are compressed to their elastic limit. Pressed to that limit and left there, or beyond that point/limit, the springs will degrade -- and some will degrade rapidly.
Why would a gun designer allow that? Because people demand it of them: many shooters want more rounds in smaller guns. Some of the subcompact guns, like the Rohrbaugh R9, have recoil springs that are pushed to their limit, and are designed to last only 250 +/- rounds. Each shot compresses the springs to their elastic limit -- and while they aren't KEPT compressed, the damage is still done. Some magazine springs are that way, too. (I'd be curious to see how long one of the R9 recoil springs would last if the gun was stored with the slide locked open...)
Working a spring isn't the only way to wear it out. Many springs, when compressed, have reserve power (i.e., they're not near their elastic limit.) If you think working a spring is what kills it, tell us how many auto tappet springs you've ever heard of breaking or otherwise failing (i.e., getting soft). Those springs may cycle MANY MILLIONS of times over the life of a car and they almost never fail. Those TAPPET SPRINGS, like
some recoil and mag springs, are designed so that when compressed, there is plenty of reserve left -- they never really get close to their ELASTIC LIMIT.)
There's arguably no simple rule about spring life that can be applied to all guns and all applications,
but spring makers, like Wolff, recommend downloading a round or two for LONG TERM STORAGE when the mags are hi-caps (or compacts with mags that hold a relatively high number of rounds.)
Some gun designers consider springs RENEWABLE RESOURCES that aren't intended to last forever. And we buy those guns because they're smaller and hold a lot of rounds...
(This topic has come up a number of times on this forum, and we've had input from a couple of engineers who work with steel, and also from a Metallurgist, an engineer who specializes in metal applications. They all agree that metal and nearly all other materials will degrade when pushed to their limits -- wood, plastic, rubber, steel, aluminum, etc.)