No animal or man is going to just stand there while you take "spotter" shots on him. He is going to be running,
Not always...I've seen a few misses...not all of them long range, where the deer just looked up and tried to figure out what happened.
One time, I saw a spike as I was climbing down out of a tree stand...had to stop with all my weight on a not so good part of the ladder...just as I shot the rung broke, the shot just barely, and I mean BARELY, cut the hide on the deers front leg...now I was busy for a second trying not to fall (I succeeded) but my buddy was only about 70 yards away.
He said the deer "flicked" its leg like a fly had bitten him, I didn't see that part, but there was a fresh "mark" on the deers leg...not even enough to bleed, just took the hair off more or less...but what I did see was him go back to browsing for acorns like nothing happened.
I got him with the 2nd shot...the rifle was a 25-06...the deer was within 100 feet through the whole ordeal.
A couple of years back...the scope on my sons 308 went bad, he shot at a deer that was appx. 275 yards away 5 times...hitting within 3-5 feet of it every time...the deer never ran, just looked around trying to figure out what all the noise was about...my son got him with my rifle after he emptied his.
I missed one (yeah, it happens) at just over 300 yards 2 years ago...only missed him by about 12" (I think it was a bad reload)...it startled him a bit, but he just looked when the bullet kicked up dirt, then went back to browsing.
They have a hard time associating the bullet with the gunshot when it comes from a distance...they don't generally run, and if they do...it ain't far because they aren't sure which way they need to go.