Google,----> N - Acetyl Cysteine Noise damage {AND} ALCAR (Acetyl Carnitine)
They are using these over the counter meds, on marines at Camp Pendelton for noise damage.
They are having favorable results.
I take them both as a preventive. I have normal hearing, but I do shoot and wear muffs, just not taking any chances.
STILL available over the counter as NAC or N-Acetyl Cysteine and Acetyl Carnitine
Sorry about length of Article
FOR IMMEDIATE RELEASE
February 2003
David Karlman
Chairman and Chief Executive Officer
American BioHealth Group, LLC
15721 Bernardo Heights Parkway Suite 151
San Diego, California 92128
(ph) 858-675-3600
(fax) 858-613-0748
[email protected]
Compound Licensed By American BioHealth Group From U.S. Navy Shown To
Protect Against Hearing Loss From Noise
SAN DIEGO, California, February 24, 2003 -- American BioHealth Group LLC (ABG), a privately held San
Diego-based company developing hearing loss prevention and treatment technology licensed exclusively
from the U.S. Navy, announced today that positive pre-clinical data on that technology were presented in at the Association for Research in Otolaryngology (ARO) Meeting held in Daytona Beach, Florida
February 23 -27, 2003.
In the poster presentation, submitted by Army Colonel Richard D. Kopke, MD, and other researchers at
DOD Spatial Orientation Center, Naval Medical Center, San Diego and the Center for Hearing and
Deafness, State University of New York at Buffalo, pre-clinical data were presented demonstrating that
administration of the antioxidant N-acetylcysteine (NAC) decreased acute noise-induced hearing loss (NIHL) due to loud impulse noise exposure.
This new data extends previous research indicating that NAC is
protective against loud continuous noise such as jet engine noise.
In the reported study, NAC, given in a basic science model before and after simulated M-16 rifle fire
consisting of 150 shots over 75 seconds reduced permanent hearing loss by over 70%.
A similar reduction in damage to the cochlear hair cells was also noted. In other related research presented by the Naval Medical Center group at ARO, data were reported indicating that two key mechanisms of inner ear injury
were depletion of inner ear glutathione and damage to mitochondria. Glutathione is a key inner ear
antioxidant and NAC replenishes the inner ear glutathione depleted by loud noise.
In addition, in a related presentation at the annual meeting of the National Association for Hearing
Conservation in Dallas, Texas just prior to the ARO meeting, the Navy group reported that a mitochondrial
protectant known as acetyl-L-Carnitine (ALCAR), also licensed by ABG from the U.S. Navy, effectively
reduced permanent hearing loss due to acute trauma from continuous noise, both when given as prevention before the noise and when given hours later as treatment.
“Based on these and other findings, NAC and a broader family of antioxidant compounds, like ALCAR,
licensed by ABG appear to be effective hearing loss protection therapies,” stated David Karlman, Chairman
and Chief Executive Officer of American BioHealth Group.
“These compounds have now been shown to effectively prevent both acute and chronic hearing loss, as well significant and growing healthcare issue in
our society today, as treat acute hearing loss, in models of various noise insults and cancer therapies.
These compounds represent the only therapy that addresses all aspects of the postulated mechanisms of
hearing loss due to noise, including free radical generation, glutamate excitotoxicity, glutathione depletion,
mitochondrial injury, and programmed cell death.
“Currently there is no pharmaceutical product in the marketplace targeted at these indications, and our goal is to develop a series of products based on the technology that addresses this significant unmet medical need,” added Karlman.
“Potential clinical uses include hearing loss prevention in high-noise work and training environments and in environments where people are exposed to a combination of noise and toxins, such as military flight lines and certain industrial settings; protection against recreational noise hazards such as shooting; and treatment for acute acoustic injury as well as hearing loss due to genetic predisposition, chemotherapy treatment, and aging.”
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