In the two ISHOT1000 matches held so far, barring a clear reason for problems (out-of-spec reloads/poor quality ammunition/overlubrication/faulty magazine) it seems that most decent autopistols will malfunction 5 times or less in 1000 rounds.
It's important to understand that some of those malfunctions may be user induced, some may be ammunition related and some may be due to issues with the gun. With a malfunction rate that low it's not really possible (except in unusual circumstances) to point at a definitive cause.
Based on those results, as a
very rough rule of thumb, if your autopistol is malfunctioning more than 5 times in 1000 rounds then you need to look for a reason because something's definitely wrong with either the gun, your technique(s), and/or the ammunition.
1,000 rounds in a self defense situation
That's not the point.
First of all, a decent semi-auto will not malfunction very much (see above) so if you want to find patterns of malfunctions you have to shoot it a lot.
Second, YOU are part of the reliability equation. Sure, the gun can handle 1000 rounds, but can you? Is your gun still reliable if your grip is getting a bit less firm from being tired after shooting all day?
Virtually any semi-auto will malfunction under the proper (improper?) circumstances. Learning those circumstances will make you, your ammo & your gun a more reliable combination. For example, I found that the Ruger P95 I used in the test was more reliable when using the slingshot method (vs. using the slide release) when chambering a round from the magazine. The issue didn't show up until round 970 of the test--then it happened twice. After the test I shot another 100 rounds or so using the slingshot method to reload and never had another malfunction. On the one hand, a person could blithely say: "Well, don't shoot 900 rounds through your gun without cleaning it and it will never be an issue." Or, one could think a little more and say: "If this gun ever gets dirty (perhaps from being dropped in a struggle) it may jam if I reload using the slide release but probably won't if I slingshot the slide."
In addition, it was possible to look at the data gathered across all the guns tested and notice that in general, all of the guns seemed to malfunction less often during reloading if the slingshot method was used.