I would suggest Winchester 145 gr. Silvertips or Speer 158 gr. Gold Dots. These rounds will be kind to your forcing cone and top strap and are more likely to penetrate the possible arm or two, thick clothing, and layer after layer of fat and muscle that might stand between you and the "vitals" of your adversary. Have no concern for losing power with a 2.5" .357 barrel. I have chronographed the Win 145 gr. Silvertip load at 1241 from a S&W 2.5" .357 barrel. (It's factory rated at 1290 fps from a 4" vented barrel). For use in K & L frame Smiths and Ruger GP's, these rounds will be quite controllable.
For use in J-frame and SP- frame .357 magnum revolvers, I am using handloaded:
135 gr. Gold Dot bullet over 7.0 gr. of PowerPistol = 967 fps from my 640's 2.125" barrel. The .38 spl. +P version develops about 860 fps from a 2" barrel, so this loading pumps up the energy nicely without exceeding the speed limit for this bullet. This for summer use with the 640 and SP-101.
158 gr. Gold Dot bullet over 8.0 gr. of Power Pistol = 1053 fps from the 2.125" barrel. This is definitely in the range of .357 loadings, but still somewhat moderate. This for fall, winter, spring use with the 640 and SP-101.
I plan to also test out Winchester's 145 gr. Silvertip bullet over 8.0 gr. of PowerPistol... yielding a "lite" .357 magnum load. I estimate that it will make about 1100 fps from the 2.125" barrel on my S&W 640.
My intent here is not to make the hottest loads available, but to make loads with low end .357 power without the heavy recoil resulting from full-house mag loads in small frame revos. These handloads are quite justifiable for defense use as they are milder than full-house magnum factory loads, which makes them more controllable and accurate for me to shoot from a small frame .357 revolver.