Anything less than a perfect head shot will just upset them. Remember always use enough gun.
Well, you never know.
I have seen the little beasts take full bore hits from a shotgun, and still hit the ground and run. They are tougher than you would think.
So are porcupines. I once saw one take a hit with a .410 slug at about twenty feet. It just got up and kept walking, and it took another shot to finish it.
I have alot of respect for wild animals. You almost have to hunt them to understand how tough they can be.