On my 640 (.357 version), I have the CT305 grips. On my M&P 340, I have the CT405 grips. Other j-frames, since sold, included a 442, 360, 60, and Pro 60. I've used Pacmayr Compacs, the S&W Compac variant, Altamont boot grips, and the Hogue pictured above. I tried a grip setup like yours on a Model 42 once, and that was enough.
The ammo I typically shoot are reloads that are 1) "GDSB 38+P" replicas; 2) "FBI800" replicas boosted to CIP specs, and 3) a "FBI900" load I developed as a shootable 357 load in a lightweight.
All the grips will work--once your hand is toughened enough through repetitive shooting, and maybe even exercises. I will admit that, after doing the 'short-barrel reloading tests' a few years ago, I found I have a new larger callous and bone deformation in the web of my shooting hand. This year, that anomaly has paid off as I have started to shoot more and get the muscles back in shape.
Once your hand is tough enough to have a death grip on the revolver while still maintaining the finer motor control for trigger squeeze and recoil, the problem will go away, I think.
Jim H.