Aside from what has already been posted, I will offer up the following.
I have been hunting with handguns for nearly 25yrs. In that I have used everything from a Blackhawk in 30 Carbine to my Raging Bull in 454. Of all of those I have shot but three deer, one with my GP-100 in .357, one with my Redhawk in 41mag, and one with my 454. The 41 and 454 were both finishing shot to be correct, but they both did exactly what was needed and anchored the deer on the spot.
What I can say is that young eyes make things a ton easier, but so does a rest and optics make thing even more reliable. If or when you DO decide to try out a piece of glass, don't cheap out get the good stuff. Also don't go with power, a 2X will serve you well.
For loads, I cannot suggest anything in a 460, but I can say that I am using the Lee 452-300RF in my 454 loaded to mid 1500's. It is more than enough to do anything you need done and isn't overly demanding on your hand or wrist to shoot 30, 50, or even more of. I load them over a good dose of 296 in Starline cases. If you check around there are some really good WFN or similar type cast bullets with gas checks that will work really well in this caliber. Also don't get caught up in having to have super hard cast bullets as mine are only out of straight air cooled clip on wheel weights of around a 14 BHN and they do wonderfully up to around 1700fps. That's as high as I wanted wanted to push them. Just in case your curious as to how they do, here is a short clip of one hitting some 6 gallon buckets of water at 50yds,
Lee C452-300-RF Water Test....
The recovered bullet (middle) found laying on the ground after passing through two buckets, and almost into but just leaving a perfect indention in the third.
The last hog I shot with one was lasered at 87 yards, and literally rolled it rear over ears after hitting it behind the onside shoulder and exiting in front of the offside.