I've got a bunch of 45s. I like them all! But for HD, in my safe i keep a para double stack 14.45 loaded, if i have to grab something for HD. it's big, heavy, & has a lot of capacity.. 14+1. I have autos, revolvers, glock, xd, ati, & regular 1911s, & they each have their strong points, but for HD, the para is the one i'd grab.
For accuracy & fun range shooting, the revolvers are the best. More accurate than the autos (in my fumbling hands), & you don't have to pick up the brass. I can reload swc, or just about anything in them, while the autos can grumble about anything but ball.
For CC, i either have the glock 30s, which is very small, lightweight & snappy, or the ATI fatboyLW, which is heavier but about the same size. They are 10+1 & 12+1 respectively. For 'do anything' 45s, either of those would be good choices, but the glock is probably more reliable.
A revolver wouldn't be a bad choice in HD, either. 6 rounds of HD ammo with some moonclips for backup & you would have a capable defense weapon. No issues with feeding, no jams, goes bang every time. Get the new ruger redhawk, & you can shoot hot 45 colt loads through it, too.
Good luck with your choice.. you can always change your mind & go another direction.