My 2 cents
I would say that the absolute best thing you can do is go to a firearms dealer or a gun show, and pick them up.. get a feel for what fits YOU. Find a model that naturally comes up to an aim point that you want to fire on. Grip it tight, grip it loose, fiddle with the controls. You might find that a Jennings 22 fits you 1000 times better than a Ruger 22/45. If it doesn't feel good, if it doesn't feel natural, it will do you NO good whatsoever.
GOOD LUCK
Paul