Almost all modern HP ammo is designed to do the same things:
1 - feed in most modern guns
2 - develop enough velocity to penetrate to 12-18" in fabric-covered gel (the "FBI test")
3 - expand signifigantly (also part of the "FBI test")
... the differences between the various defensive ammunition choices in any given caliber are minimal, reliability matters too much more to waste time worrying about those minimal differences.
So, seeing as they all do pretty much the same thing, don't overthink your choice of exact load, in fact you should at least be aware of 2-3 loads that function in most of your guns (in my case, that's; Gold Dots, Critical Defense, PDX1, EFMJ, ... those loads feed in all my modern autoloaders, others {surplus/oddball guns} have specialized needs)
So you'll need a box or two of anything promising to test in your carry/defense gun(s). Once you know what works, buy cheap and stack deep - which means no more stupid 20 or 25 round boxes for $1/round if you can avoid it. (I don't remember the last time I saw a 50x box of Crit.Def. in the wild, now that I think about it)