I'm a fan of all the main defense calibers. 9mm, .40, .357 SIG, .45 ACP, and even the 10mm. We all have our favorites but few want to admit that a handgun is "only" a handgun. And in the greater scheme of things it doesn't really make that much of a difference which you choose. I've read a few "real life" reports where citizens had to use their handgun for self defense at GlockTalk, SIGForum, 1911Forum, and elsewhere. And whether they were using a 9mm or a .45 what got them through was their training and a willingness to fight. Not the type of gun or caliber they used.